New immunotherapies in breast cancer

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The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease. Use of ICB as monotherapy has achieved objective responses in patients with breast cancer, with higher rates seen when administered in earlier lines of therapy. For responding patients, those responses are durable.

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Xconomy New York —. Merck this morning announced that a combination of its drug pembrolizumab Keytruda and chemotherapy succeeded in a Phase 3 study in breast cancer, a potentially notable advance for immunotherapy in treating the disease. Without providing details, Merck said that Keytruda-chemo led to a statistically significant improvement in pathological complete responses for these patients—that is, there was no trace of cancer on tissue samples taken after therapy and surgery.

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Chiles Research Institute, Portland, Oregon. Importance: There is tremendous interest in using immunotherapy to treat breast cancer, as evidenced by the more than clinical trials ongoing at the time of this narrative review. The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease. Observations: After searching ClinicalTrials.

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Until now, people with inoperable triple-negative breast cancer had one treatment option: chemotherapy. But this month, the U. Food and Drug Administration FDA granted accelerated approval to the first immunotherapy treatment for breast cancer.

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This is an exciting time in metastatic breast cancer research. Many new treatments for metastatic breast cancer are under study and treatment is improving. Findings from clinical trials will determine whether or not new treatments will become a part of standard care for metastatic breast cancer.

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Early results show reduction in recurrence of triple negative breast cancer when treated with immunotherapy along with chemotherapy. Triple negative breast cancer is an aggressive form of breast cancer that is diagnosed when the cancerous tumour tests negative for three receptors: the hormones oestrogen and progesterone, and the HER2 protein. The uncommon cancer is typically treated by surgery and chemotherapy, Cancer Research UK says.

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Some target a particular part of the cancer cell others use the immune system to kill cancer cells. Targeted cancer drugs are treatments that change the way cells work and help the body to control the growth of cancer. Our immune system works to protect us against diseases, including cancer. It normally picks up faulty cells and destroys them.

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Immunotherapy can be used to treat some types of breast cancer. An important part of the immune system is its ability to keep itself from attacking normal cells in the body. Breast cancer cells sometimes use these checkpoints to avoid being attacked by the immune system.

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