This means that the breast cancer cells have tested negative for hormone epidermal growth factor receptor 2 HER-2estrogen receptors ERand progesterone receptors PR. In fact, triple negative breast cancer may respond even better to chemotherapy in the earlier stages than many other forms of cancer. Triple negative breast cancer can be more aggressive and difficult to treat.
A cancer diagnosis often brings about feelings of fear and anxiety. But when the diagnosis is triple negative breast cancer TNBCthe patient often experiences even more anxiety when she learns about the high recurrence rates and lack of targeted drug treatments available for this particular subtype of breast cancer. Helping patients understand the disease, how it is treated, and dispelling myths related to it are important factors to improve their ability to cope with their diagnosis.
Aim: Triple-negative breast cancer has a poor prognosis due to its aggressive behaviour and lack of effective targeted therapies. Patients and Methods: Patients diagnosed with stage I-III triple-negative breast cancer at our Institution were included in the analysis. The impact of various factors age, menopausal status, tumor characteristics, adjuvant treatment, etc.
Some questions you may have are:. The answer to those and other questions you have will depend on a lot of factors, such as the stage of the cancer and how well it responds to treatment. Keep reading to learn more about TNBC and your outlook.
One of these subtypes is known as triple-negative breast cancer TNBC. TNBC grows rapidly. It also has a higher grade and tends to metastasize spread.
An important part of diagnosing breast cancer is staging. Staging is the process of finding out how much cancer there is and where it is located. This information is used to plan cancer treatment and estimate a prognosis.
Basal-like tumors have cells that look similar to those of the outer basal cells surrounding the mammary ducts. Most triple negative tumors are basal-like and most basal-like tumors are triple negative see figure below. About percent of breast cancers are triple negative or basal-like .
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Triple negative is sometimes used as a surrogate term for basal-like ; however, more detailed classification may provide better guidance for treatment and better estimates for prognosis. Triple-negative breast cancers comprise a very heterogeneous group of cancers. There is conflicting information over prognosis for the various subtypes, but it appears that the Nottingham prognostic index is valid and hence general prognosis is rather similar with other breast cancer of same stage, except that more aggressive treatment is required. Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of relapse is much higher for the first 3—5 years, but drops sharply and substantially below that of hormone-positive breast cancers afterwards.